In Vivo pharmacology efficacy studies provide critical “proof of concept” for advancing an NCE.

At present, Vimta has the requisite expertise to deliver on the following efficacy models across therapeutic areas.

Pain and Inflammatory models:

• CFA/Carrageenan induced hyperalgesia in rats


• Carrageenan and LPS induced paw edema in rats
 
• LPS (i.p) induced TNF α release in rats


• Acetic acid induced writhing in mice


• Oxazolone induced ear edema in mice


• TNBS - induced colitis in rats


• Ova sensitized model of asthma in Guinea pigs

Thermal & Mechanical Hyperalgesia

Assessment of thermal hyperalgesia is carried out in rats and or mice using the following methods: Hot plate or radiant heat in the Tail Flick model, or in the Plantar test using Hargreaves method. Mechanical hyperalgesia is assessed using Randall-Selitto apparatus for measuring paw pressure. Tactile allodynia is measured using the Electronic Von Frey filaments.

Neuropathic pain models

• PSNL induced neuropathic pain in rats


• Diabetic Neuropathic Pain (DNP) in rats