1. Xenograft model
2. In vivo target inhibition model

Vimta Life Sciences provides state-of-the-art preclinical xenograft models with multiple cell lines to support preclinical research and assessment of anticancer drugs. Our expert scientific staffs possess strong industrial and academic backgrounds. With our new and complete laboratory facilities, validated xenograft models and supporting studies, Vimta life sciences is able to support a complete discovery and development program for anti-cancer drugs.

We have established multiple in vitro and in vivo assay systems to evaluate novel anti-cancer compounds. Each assay is designed to understand specific aspects of drug property and its mechanism of action. By accessing our comprehensive capability, our customers can advance development programs in a timely and cost-effective manner. Vimta Life Sciences scientists have extensive experience with the design and execution of efficacy studies for all types of experimental cancer therapeutic agents including both small molecules and biologics. Our current cancer pharmacology service portfolio includes- Human Xenograft Model.

Human xenograft models are generated by inoculating a tumour cell lines into an immunodeficient rodent such as nude mice or SCID mice. This is a subcutaneous xenograft models. This model involves implantation of tumour cells via subcutaneous injection into the flank of nude mice or SCID mice. This model provides consistent and reproducible cell growth and permits easy access to the tumour for treatment and calliper measurement. We offer traditional subcutaneous models and other models and can customize models to meet a sponsor’s needs.

• Human tumour cells grown in culture (ATCC or custom lines)
• Cell implant subcutaneously into immuno-compromised animals
• Tumours measured during growth phase
• Animals treated with vehicle, test article, and positive controls
• Various protocol-specified parameters/markers assessed ex vivo or in vivo assays
• Report preparation

VIMTA Life Sciences scientific teams not only investigate the effect of test article on tumour growth but also actively participate in investigating the mode of action. In PK/PD studies the tumours are excised from the test article treated mice group along with respective control groups. Then the effect of test article at molecular level is investigated in different cell based assays. The MTD of the compound is also analysed.