DMPK studies are conducted to determine the disposition of the drug and its metabolites using suitable animal models. At Vimta we offer the following DMPK services

• Single or multiple dose (s) – in mice & rats


• Oral &/or IV or IP (or intended) route


• 2-6 animals/dose; 5-12 time points / client specific designs


• PK study in cannulated animals as per client's requirement


• Tissue distribution studies


• In -vivo blood – brain barrier penetration studies

End-points

• Oral BA


• Elimination half life (t1/2) Clearance (Cl) Volume Distribution (Vd)


• Metabolite identification